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  3. Drug Derivative
  4. 2348493-39-8

2348493-39-8

NUC-7738 Chemical Structure

2348493-39-8

Chemical Structure

  • NUC-7738
  • CAS No: 2348493-39-8
    Formula: C26H29N6O7P
    Molecular Weight: 568.52
  • IUPAC Name: benzyl ((((2S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate
  • InChIKey: UDLWWGQHMQIYCV-LKKHFEEPSA-N
  • SMILES: NC1=NC=NC2=C1N=CN2[C@@H]3O[C@H](COP(N[C@@H](C)C(OCC4=CC=CC=C4)=O)(OC5=CC=CC=C5)=O)C[C@H]3O

Biological Activity: NUC-7738, an aryloxy phosphoramidate of 3′-Deoxyadenosine, is a 5′-aryloxy phosphoramidate prodrug of 3′-Deoxyadenosine (3′-dA). NUC-7738 has potent cytotoxic activity against a panel of hematological cancer cell lines. NUC-7738 can be used in research of cancer[1].

Cat. No. Product Name Purity Description
HY-136506 NUC-7738 97.09% NUC-7738, an aryloxy phosphoramidate of 3′-Deoxyadenosine, is a 5′-aryloxy phosphoramidate prodrug of 3′-Deoxyadenosine (3′-dA). NUC-7738 has potent cytotoxic activity against a panel of hematological cancer cell lines. NUC-7738 can be used in research of cancer.

References

[1]. Serpi M, et, al. Synthesis and Characterization of NUC-7738, an Aryloxy Phosphoramidate of 3'-Deoxyadenosine, as a Potential Anticancer Agent. J Med Chem. 2022 Dec 8;65(23):15789-15804. [Content Brief]

Keywords:

NUC-7738