2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. 2138299-65-5

2138299-65-5

diABZI-4 Chemical Structure

2138299-65-5

Chemical Structure

  • diABZI-4
  • CAS No: 2138299-65-5
    Formula: C40H51Cl2N13O6
    Molecular Weight: 880.82
  • InChIKey: OZNAUXMXFFKBFU-BGNBUWATSA-N
  • SMILES: O=C(C1=CC(C)=NN1CC)NC2=NC3=CC(C(N)=O)=CC(OC)=C3N2C/C=C/CN4C5=C(OCCCN(C)C)C=C(C(N)=O)C=C5N=C4NC(C6=CC(C)=NN6CC)=O.Cl.Cl

Biological Activity: diABZI-4 is an oral active STING agonist with broad-spectrum antiviral activity. diABZI-4 induces the production of pro-inflammatory cytokines and lymphocyte activation by activating STING, thereby inhibiting the replication of influenza A virus (IAV), SARS-CoV-2, and human rhinovirus (HRV), with an EC50 range of 11.8-199 nM[1][2].

Cat. No. Product Name Purity Description
HY-168034 diABZI-4 diABZI-4 is an oral active STING agonist with broad-spectrum antiviral activity. diABZI-4 induces the production of pro-inflammatory cytokines and lymphocyte activation by activating STING, thereby inhibiting the replication of influenza A virus (IAV), SARS-CoV-2, and human rhinovirus (HRV), with an EC50 range of 11.8-199 nM.

References

[1]. Broeckel R, et al. STING Agonist Induced Innate Immune Responses Drive Anti-Respiratory Virus Activity In Vitro with Limited Antiviral Efficacy In Vivo. ACS Infect Dis. 2024 Sep 13;10(9):3392-3407. [Content Brief]
[2]. Humphries F, et al. A diamidobenzimidazole STING agonist protects against SARS-CoV-2 infection. Sci Immunol. 2021 May 18;6(59):eabi9002. [Content Brief]

Keywords:

diABZI-4