2. PROTAC
  3. Ligands for E3 Ligase
  4. 2375196-30-6

2375196-30-6

KB02-COOH Chemical Structure

2375196-30-6

Chemical Structure

  • KB02-COOH
  • CAS No: 2375196-30-6
    Formula: C13H14ClNO4
    Molecular Weight: 283.71
  • IUPAC Name: 2-((1-(2-chloroacetyl)-1,2,3,4-tetrahydroquinolin-6-yl)oxy)acetic acid
  • InChIKey: ZWIYQLVGARZWJJ-UHFFFAOYSA-N
  • SMILES: O=C(O)COC1=CC2=C(N(C(CCl)=O)CCC2)C=C1

Biological Activity: KB02-COOH is a fragment of synthesis of ubiquitin E3 ligase ligand KB02. KB02 can be used in the synthesis of PROTAC, such as KB02-JQ1 (HY-129917) and KB02-SLF (HY-129610)[1].

Cat. No. Product Name Purity Description
HY-131385 KB02-COOH 99.39% KB02-COOH is a fragment of synthesis of ubiquitin E3 ligase ligand KB02. KB02 can be used in the synthesis of PROTAC, such as KB02-JQ1 (HY-129917) and KB02-SLF (HY-129610).

References

[1]. Zhang X, et al. Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16. Nat Chem Biol. 2019 Jul;15(7):737-746. [Content Brief]

Keywords:

KB02-COOH