2. Others Vitamin D Related/Nuclear Receptor
  3. Isotope-Labeled Compounds Progesterone Receptor
  4. 1061354-48-0

1061354-48-0

AVN-101 hydrochloride Chemical Structure

1061354-48-0

Chemical Structure

  • AVN-101 hydrochloride
  • CAS No: 1061354-48-0
    Formula: C21H25ClN2
    Molecular Weight: 340.89
  • IUPAC Name: 2,8-dimethyl-5-phenethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole hydrochloride
  • InChIKey: RKLJJDFIWWRTEJ-UHFFFAOYSA-N
  • SMILES: CC1=CC2=C(C=C1)N(C3=C2CN(CC3)C)CCC4=CC=CC=C4.[H]Cl

Biological Activity: AVN-101 hydrochloride is a potent, brain-penetrant and orally active 5-HT7 receptor antagonist (Ki of 153 pM), with slightly lesser potency toward 5-HT6, 5-HT2A, and 5HT-2C receptors (Ki values of 2.04 nM, 1.56  nM, and 1.17  nM, respectively). AVN-101 hydrochloride also exhibits a rather high affinity toward histamine H1 (Ki of 0.58 nM) and adrenergic α2A, α2B, and α2C (Ki= 0.41-3.6 nM) receptors. AVN-101 hydrochloride can be studied in such diseases as general anxiety disorders, depression, schizophrenia, and multiple sclerosis[1].

Cat. No. Product Name Purity Description
HY-117046A AVN-101 hydrochloride 99.59% AVN-101 hydrochloride is a potent, brain-penetrant and orally active 5-HT7 receptor antagonist (Ki of 153 pM), with slightly lesser potency toward 5-HT6, 5-HT2A, and 5HT-2C receptors (Ki values of 2.04 nM, 1.56  nM, and 1.17  nM, respectively). AVN-101 hydrochloride also exhibits a rather high affinity toward histamine H1 (Ki of 0.58 nM) and adrenergic α2A, α2B, and α2C (Ki= 0.41-3.6 nM) receptors. AVN-101 hydrochloride can be studied in such diseases as general anxiety disorders, depression, schizophrenia, and multiple sclerosis.

References

[1]. Alexandre V Ivachtchenko, et al. AVN-101: A Multi-Target Drug Candidate for the Treatment of CNS Disorders. J Alzheimers Dis. 2016 May 25;53(2):583-620. [Content Brief]

Keywords:

AVN-101 hydrochloride