2. Immunology/Inflammation
  3. PD-1/PD-L1
  4. 3031353-59-7

3031353-59-7

MS159 Chemical Structure

3031353-59-7

Chemical Structure

  • MS159
  • CAS No: 3031353-59-7
    Formula: C43H40N8O10
    Molecular Weight: 828.83
  • IUPAC Name: N-cyclopropyl-N-(4-((5-(3-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamido)propoxy)pyridin-2-yl)carbamoyl)benzyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carboxamide
  • InChIKey: OBZWKPGPTCBYOS-UHFFFAOYSA-N
  • SMILES: O=C(NCCCOC1=CN=C(C=C1)NC(C2=CC=C(C=C2)CN(C3CC3)C(C4=CC=C5NC(COC5=C4)=O)=O)=O)CNC6=CC=CC7=C6C(N(C7=O)C8CCC(NC8=O)=O)=O

Biological Activity: MS159 is a potent nuclear receptor binding SET structural domain protein 2 (NSD2) PROTACdegrader. MS159 inhibits the growth of tumour cells. MS159 is a useful chemical tool for exploring the role of NSD2 in health and disease[1].

Cat. No. Product Name Purity Description
HY-151101 MS159 98.28% MS159 is a potent nuclear receptor binding SET structural domain protein 2 (NSD2) PROTACdegrader. MS159 inhibits the growth of tumour cells. MS159 is a useful chemical tool for exploring the role of NSD2 in health and disease.

References

[1]. Fanye Meng, et al. Discovery of a First-in-Class Degrader for Nuclear Receptor Binding SET Domain Protein 2 (NSD2) and Ikaros/Aiolos. J Med Chem. 2022 Aug 11;65(15):10611-10625. [Content Brief]

Keywords:

MS159