2. Anti-infection
  3. Bacterial
  4. 2411741-01-8

2411741-01-8

Antituberculosis agent-2 Chemical Structure

2411741-01-8

Chemical Structure

  • Antituberculosis agent-2
  • CAS No: 2411741-01-8
    Formula: C19H17NO4
    Molecular Weight: 323.34
  • IUPAC Name: 5-(azetidin-1-ylmethyl)-6-hydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
  • InChIKey: YONQTMXRNDKBLV-UHFFFAOYSA-N
  • SMILES: O=C1C=C(C2=CC=C(O)C=C2)OC3=CC=C(O)C(CN4CCC4)=C13

Biological Activity: Antituberculosis agent-2 (Compound 8d) is an antituberculosis agent against agent-sensitive and multidrug-resistant tuberculosis. Antituberculosis agent-2 shows anti-tuberculosis activity with MIC values of 0.454, 1.757 and 1.644 μg/mL against M. tuberculosis H37Rv, 13946 and 14862, respectively. Antituberculosis agent-2 displays favorable mouse and human microsomal stability, low cytotoxicity, and acceptable oral bioavailability[1].

Cat. No. Product Name Purity Description
HY-146057 Antituberculosis agent-2 Antituberculosis agent-2 (Compound 8d) is an antituberculosis agent against agent-sensitive and multidrug-resistant tuberculosis. Antituberculosis agent-2 shows anti-tuberculosis activity with MIC values of 0.454, 1.757 and 1.644 μg/mL against M. tuberculosis H37Rv, 13946 and 14862, respectively. Antituberculosis agent-2 displays favorable mouse and human microsomal stability, low cytotoxicity, and acceptable oral bioavailability.

References

[1]. Zhao W, et al. Design, synthesis, and biological evaluation of novel 4H-chromen-4-one derivatives as antituberculosis agents against multidrug-resistant tuberculosis. Eur J Med Chem. 2020 Mar 1;189:112075. [Content Brief]

Keywords:

Antituberculosis agent-2