2. Anti-infection
  3. HIV
  4. 2437547-04-9

2437547-04-9

CCR6 inhibitor 1 Chemical Structure

2437547-04-9

Chemical Structure

  • CCR6 inhibitor 1
  • CAS No: 2437547-04-9
    Formula: C24H23F3N4O3S
    Molecular Weight: 504.52
  • IUPAC Name: 4-(4-(((1r,4r)-4-((5-(trifluoromethyl)pyridin-2-yl)amino)cyclohexyl)sulfonyl)phenyl)picolinamide
  • InChIKey: CNOZLNNAVQPFBD-KESTWPANSA-N
  • SMILES: O=S([C@H](CC1)CC[C@@H]1NC2=NC=C(C(F)(F)F)C=C2)(C3=CC=C(C4=CC=NC(C(N)=O)=C4)C=C3)=O

Biological Activity: CCR6 inhibitor 1 is a potent and selective CCR6 inhibitor, with IC50s of 0.45 and 6 nM for monkey and human CCR6, much more selective at CCR6 over human CCR1 (IC50, > 30000 nM), and CCR7 (IC50, 9400 nM). CCR6 inhibitor 1 markedly blocks ERK phosphorylation. CCR6 inhibitor 1 is used in the research of autoimmune diseases and cancer[1].

References

[1]. Tawaraishi T, et al. Identification of a novel series of potent and selective CCR6 inhibitors as biological probes. Bioorg Med Chem Lett. 2018 Oct 1;28(18):3067-3072. [Content Brief]

Keywords:

CCR6 inhibitor 1