2. Neuronal Signaling NF-κB
  3. Cholinesterase (ChE) Keap1-Nrf2
  4. 2417117-84-9

2417117-84-9

AChE/Nrf2 modulator 1 Chemical Structure

2417117-84-9

Chemical Structure

  • AChE/Nrf2 modulator 1
  • CAS No: 2417117-84-9
    Formula: C27H27FN4O2
    Molecular Weight: 458.53
  • IUPAC Name: 5-(3-((1-(3-fluorobenzyl)piperidin-4-yl)methoxy)phenyl)-3-(6-methylpyridin-3-yl)-1,2,4-oxadiazole
  • InChIKey: RRSJHXGJAMBCDJ-UHFFFAOYSA-N
  • SMILES: CC1=CC=C(C=N1)C2=NOC(C3=CC(OCC4CCN(CC4)CC5=CC(F)=CC=C5)=CC=C3)=N2

Biological Activity: AChE/Nrf2 modulator 1 is an orally active acetylcholinesterase (AChE)/nuclear factor erythroid 2-related factor 2 (Nrf2) modulator. AChE/Nrf2 modulator 1 has Nrf2 inductive activity and AChE inhibitory activity for eeAChE and hAChE with IC50 values of 0.07 μM and 0.38 μM, respectively. AChE/Nrf2 modulator 1 can be used for the research of Alzheimer's disease[1].

Cat. No. Product Name Purity Description
HY-152037 AChE/Nrf2 modulator 1 AChE/Nrf2 modulator 1 is an orally active acetylcholinesterase (AChE)/nuclear factor erythroid 2-related factor 2 (Nrf2) modulator. AChE/Nrf2 modulator 1 has Nrf2 inductive activity and AChE inhibitory activity for eeAChE and hAChE with IC50 values of 0.07 μM and 0.38 μM, respectively. AChE/Nrf2 modulator 1 can be used for the research of Alzheimer's disease.

References

[1]. Yuanyuan Wang, et al. Design, synthesis and evaluation of fused hybrids with acetylcholinesterase inhibiting and Nrf2 activating functions for Alzheimer's disease. Eur J Med Chem. 2022 Dec 15;244:114806. [Content Brief]

Keywords:

AChE/Nrf2 modulator 1