2. Anti-infection Immunology/Inflammation GPCR/G Protein
  3. Fungal CXCR
  4. 2428393-60-4

2428393-60-4

Corydalmine hydrochloride Chemical Structure

2428393-60-4

Chemical Structure

  • Corydalmine hydrochloride
  • Synonym(s): L-Corydalmine hydrochloride; TLZ-16-CL
  • CAS No: 2428393-60-4
    Formula: C20H24ClNO4
    Molecular Weight: 377.86
  • IUPAC Name: (S)-2,3,9-trimethoxy-5,8,13,13a-tetrahydro-6H-isoquinolino[3,2-a]isoquinolin-10-ol hydrochloride
  • InChIKey: HRYGJEUMQGYZLO-NTISSMGPSA-N
  • SMILES: OC1=CC=C2C(CN3CCC4=CC(OC)=C(OC)C=C4[C@]3([H])C2)=C1OC.[H]Cl

Biological Activity: Corydalmine hydrochloride inhibits spore germination of some plant pathogenic as well as saprophytic fungi[1]. Corydalmine hydrochloride acts as an oral analgesic agent, exhibiting potent analgesic activity[2]. Corydalmine hydrochloride alleviates Vincristine-induced neuropathic pain in mice by inhibiting an NF-κB-dependent CXCL1/CXCR2 signaling pathway[3].

Cat. No. Product Name Purity Description
HY-N2573A Corydalmine hydrochloride Corydalmine hydrochloride inhibits spore germination of some plant pathogenic as well as saprophytic fungi. Corydalmine hydrochloride acts as an oral analgesic agent, exhibiting potent analgesic activity. Corydalmine hydrochloride alleviates Vincristine-induced neuropathic pain in mice by inhibiting an NF-κB-dependent CXCL1/CXCR2 signaling pathway.

References

[1]. Basha SA, Jha RN, Pandey VB, Singh UP. Effect of 1-corydalmine,an Alkaloid Isolated from Corydalis chaerophylla Roots on Spore Germination of Some Fungi. Mycobiology. 2007;35(2):69-71. [Content Brief]
[2]. Tang X, Di X, Zhong Z, et al. In vitro metabolism of l-corydalmine, a potent analgesic drug, in human, cynomolgus monkey, beagle dog, rat and mouse liver microsomes. J Pharm Biomed Anal. 2016;128:98-105. [Content Brief]
[3]. Zhou L, Hu Y, Li C, et al. Levo-corydalmine alleviates vincristine-induced neuropathic pain in mice by inhibiting an NF-kappa B-dependent CXCL1/CXCR2 signaling pathway. Neuropharmacology. 2018;135:34-47. [Content Brief]

Keywords:

Corydalmine hydrochloride