2. Protein Tyrosine Kinase/RTK
  3. VEGFR
  4. 2439096-06-5

2439096-06-5

VEGFR-2-IN-26 Chemical Structure

2439096-06-5

Chemical Structure

  • VEGFR-2-IN-26
  • CAS No: 2439096-06-5
    Formula: C24H19F3N6O2
    Molecular Weight: 480.44
  • IUPAC Name: N-methyl-4-((4-(3-(3-(trifluoromethyl)phenyl)ureido)phenyl)amino)quinazoline-2-carboxamide
  • InChIKey: WYRDCQCFFPDLMM-UHFFFAOYSA-N
  • SMILES: O=C(NC1=CC=CC(C(F)(F)F)=C1)NC2=CC=C(NC3=C4C=CC=CC4=NC(C(NC)=O)=N3)C=C2

Biological Activity: VEGFR-2-IN-26 (compound 5h) is a highly potent VEGFR-2 inhibitor with an IC50 value of 15.5 nM. VEGFR-2-IN-26 has good antiproliferative activity against the leukemic, non-small lung, CNS, ovarian, renal, prostate and breast cancer cells[1].

Cat. No. Product Name Purity Description
HY-146230 VEGFR-2-IN-26 VEGFR-2-IN-26 (compound 5h) is a highly potent VEGFR-2 inhibitor with an IC50 value of 15.5 nM. VEGFR-2-IN-26 has good antiproliferative activity against the leukemic, non-small lung, CNS, ovarian, renal, prostate and breast cancer cells.

References

[1]. Hadi SRAE, et al. Scaffold hopping and redesign approaches for quinazoline based urea derivatives as potent VEGFR-2 inhibitors. Bioorg Chem. 2020 Aug;101:103961. [Content Brief]

Keywords:

VEGFR-2-IN-26