2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor Adrenergic Receptor
  4. 24526-64-5

24526-64-5

Nomifensine Chemical Structure

24526-64-5

Chemical Structure

  • Nomifensine
  • Synonym(s): (±)-Nomifensine; Nomifensin
  • CAS No: 24526-64-5
    Formula: C16H18N2
    Molecular Weight: 238.33
  • IUPAC Name: 2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinolin-8-amine
  • InChIKey: XXPANQJNYNUNES-UHFFFAOYSA-N
  • SMILES: NC1=CC=CC2=C1CN(C)CC2C3=CC=CC=C3

Biological Activity: Nomifensine ((±)-Nomifensine) is a potent norepinephrine (NE) and dopamine (DA) reuptake inhibitor. Nomifensine inhibits uptake of NE, DA and 5-HT in rat brain synaptosomes, with IC50 values of 6.6 nM, 48 nM and 830 nM, and Ki values of 4.7 nM, 26 nM and 4000 nM, respectively. Nomifensine shows low or ineffective binding activity to dopamine D2, α1-adrenergic, 5-HT2, and muscarinic receptors. Nomifensine has antidepressive effects[1][2].

References

[1]. Hyttel J, et al. Neurochemical profile of Lu 19-005, a potent inhibitor of uptake of dopamine, noradrenaline, and serotonin. J Neurochem. 1985 May;44(5):1615-22. [Content Brief]
[2]. Tuomisto J. Nomifensine and its derivatives as possible tools for studying amine uptake. Eur J Pharmacol. 1977 Mar 21;42(2):101-6. [Content Brief]

Keywords:

NomifensineNomifensine-d3 maleate