2. Others
  3. Drug Derivative
  4. 3026690-49-0

3026690-49-0

MenA-IN-2 Chemical Structure

3026690-49-0

Chemical Structure

  • MenA-IN-2
  • CAS No: 3026690-49-0
    Formula: C23H31ClN2O
    Molecular Weight: 386.96
  • IUPAC Name: 4-((4-((4-chlorophenoxy)methyl)piperidin-1-yl)methyl)-N-methyl-N-propylaniline
  • InChIKey: IELKIDMEJICGCF-UHFFFAOYSA-N
  • SMILES: CCCN(C1=CC=C(C=C1)CN2CCC(CC2)COC3=CC=C(C=C3)Cl)C

Biological Activity: MenA-IN-2 (Compound 11) is an inhibitor of 1,4-dihydroxy-2-naphthoate prenyltransferase (MenA). MenA-IN-2 inhibits MenA with an IC50 value of 22 µM and inhibits Mycobacterium tuberculosis (Mtb) with an GIC50 value of 10 µM. MenA-IN-2 can curb the continuous transmission of Mtb[1].

Cat. No. Product Name Purity Description
HY-152534 MenA-IN-2 99.84% MenA-IN-2 (Compound 11) is an inhibitor of 1,4-dihydroxy-2-naphthoate prenyltransferase (MenA). MenA-IN-2 inhibits MenA with an IC50 value of 22 µM and inhibits Mycobacterium tuberculosis (Mtb) with an GIC50 value of 10 µM. MenA-IN-2 can curb the continuous transmission of Mtb.

References

[1]. Berg K, et al. SAR study of piperidine derivatives as inhibitors of 1,4-dihydroxy-2-naphthoate isoprenyltransferase (MenA) from Mycobacterium tuberculosis. Eur J Med Chem. 2023 Jan 18;249:115125. [Content Brief]

Keywords:

MenA-IN-2