2. Apoptosis Cytoskeleton Cell Cycle/DNA Damage
  3. Apoptosis Microtubule/Tubulin
  4. 2478584-74-4

2478584-74-4

αβ-Tubulin-IN-1 Chemical Structure

2478584-74-4

Chemical Structure

  • αβ-Tubulin-IN-1
  • CAS No: 2478584-74-4
    Formula: C25H19N3O3
    Molecular Weight: 409.44
  • IUPAC Name: N-(3-(benzo[d][1,3]dioxol-5-yloxy)benzyl)-9H-pyrido[3,4-b]indol-3-amine
  • InChIKey: AGUNDEAVRTZOAH-UHFFFAOYSA-N
  • SMILES: C(N1)(C=NC(NCC2=CC=CC(OC3=CC=C(OCO4)C4=C3)=C2)=C5)=C5C6=C1C=CC=C6

Biological Activity: αβ-Tubulin-IN-1 is a potent and orally active αβ-Tubulin inhibitor. αβ-Tubulin-IN-1 induces cell cycle arrest at G2/M and efficient apoptosis. αβ-Tubulin-IN-1 inhibits tumor cell migration and Metastasis. αβ-Tubulin-IN-1 shows significant antitumor efficacy in a dose dependent manner[1].

Cat. No. Product Name Purity Description
HY-144132 αβ-Tubulin-IN-1 αβ-Tubulin-IN-1 is a potent and orally active αβ-Tubulin inhibitor. αβ-Tubulin-IN-1 induces cell cycle arrest at G2/M and efficient apoptosis. αβ-Tubulin-IN-1 inhibits tumor cell migration and Metastasis. αβ-Tubulin-IN-1 shows significant antitumor efficacy in a dose dependent manner.

References

[1]. Li Y, et al. Structure-Based Design and Synthesis of N-Substituted 3-Amino-β-Carboline Derivatives as Potent αβ-Tubulin Degradation Agents. J Med Chem. 2022 Feb 10;65(3):2675-2693. [Content Brief]

Keywords:

αβ-Tubulin-IN-1