2. GPCR/G Protein Immunology/Inflammation Anti-infection
  3. CXCR HIV
  4. 2728500-80-7

2728500-80-7

NF-56-EJ40 hydrochloride Chemical Structure

2728500-80-7

Chemical Structure

  • NF-56-EJ40 hydrochloride
  • CAS No: 2728500-80-7
    Formula: C27H31Cl2N3O3
    Molecular Weight: 516.46
  • InChIKey: HAGZBLXHOBYRGU-UHFFFAOYSA-N
  • SMILES: O=C(NC1=C(CC(O)=O)C=CC=C1)C2=CC=CC(C3=CC=C(CN4CCN(C)CC4)C=C3)=C2.Cl.Cl

Biological Activity: NF-56-EJ40 hydrochloride is a potent, high-affinity, and highly selective human SUCNR1 (GPR91) antagonist with an IC50 of 25 nM and a Ki of 33 nM, and shows almost no activity towards rat SUCNR1. NF-56-EJ40 hydrochloride has high affinity for humanized rat SUCNR1 with a Ki value of 17.4 nM[1].

Cat. No. Product Name Purity Description
HY-130246A NF-56-EJ40 hydrochloride NF-56-EJ40 hydrochloride is a potent, high-affinity, and highly selective human SUCNR1 (GPR91) antagonist with an IC50 of 25 nM and a Ki of 33 nM, and shows almost no activity towards rat SUCNR1. NF-56-EJ40 hydrochloride has high affinity for humanized rat SUCNR1 with a Ki value of 17.4 nM.

References

[1]. Haffke M, et al. Structural basis of species-selective antagonist binding to the succinate receptor. Nature. 2019 Oct;574(7779):581-585. [Content Brief]

Keywords:

NF-56-EJ40 hydrochloride