2. Others
  3. Amino Acid Derivatives
  4. 148619-41-4

148619-41-4

Ternatin Chemical Structure

148619-41-4

Chemical Structure

  • Ternatin
  • CAS No: 148619-41-4
    Formula: C37H67N7O8
    Molecular Weight: 737.97
  • IUPAC Name: (3S,6S,9S,12S,15R,18R,21R)-15-((S)-sec-butyl)-18-((R)-1-hydroxy-2-methylpropyl)-6,9-diisobutyl-1,3,4,10,12,13,21-heptamethyl-1,4,7,10,13,16,19-heptaazacyclohenicosane-2,5,8,11,14,17,20-heptaone
  • InChIKey: ZMFVAIFXJWEOMH-PTPSPKLBSA-N
  • SMILES: CC[C@@H]([C@@]1([H])NC([C@@](NC([C@H](N(C([C@@H](N(C([C@@H](NC([C@@H](N(C([C@@H](N(C1=O)C)C)=O)C)CC(C)C)=O)CC(C)C)=O)C)C)=O)C)C)=O)([H])[C@H](O)C(C)C)=O)C

Biological Activity: Ternatin (compound 2) is a cyclic heptapeptides that can be isolated from mushroom Coliorus versicolor. Ternatin inhibits fat-accumulation with an IC50 of 0.027 μM in 3T3-L1 adipocytes[1].

References

[1]. Kenichiro Shimokawa, et al. Structure-based hybridization of the bioactive natural products rhizonin A and ternatin leading to a selective fat-accumulation inhibitor against 3T3-L1 adipocytes. Bioorg Med Chem Lett. 2009 Feb 1;19(3):867-9. [Content Brief]

Keywords:

Ternatin