2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. 2617578-93-3

2617578-93-3

TLR4-IN-1 Chemical Structure

2617578-93-3

Chemical Structure

  • TLR4-IN-1
  • CAS No: 2617578-93-3
    Formula: C10H12O4
    Molecular Weight: 196.20
  • InChIKey: WIOBDDXXACBUIP-UHFFFAOYSA-N
  • SMILES: O=C1C(C(C)CC1C(CC(C)=O)=O)=O

Biological Activity: TLR4-IN-1 (compound 3k) inhibits the cell viability of RAW264.7 with an IC50 of 1.02 μM. TLR4-IN-1 inhibits the release of cytokine TNF-α, IL-1β and IL-6, and exhibits anti-inflammatory efficacy in rats rheumatoid arthritis models[1].

Cat. No. Product Name Purity Description
HY-163998 TLR4-IN-1 TLR4-IN-1 (compound 3k) inhibits the cell viability of RAW264.7 with an IC50 of 1.02 μM. TLR4-IN-1 inhibits the release of cytokine TNF-α, IL-1β and IL-6, and exhibits anti-inflammatory efficacy in rats rheumatoid arthritis models.

References

[1]. Zhou S, et al., Design, Synthesis, and Antirheumatoid Arthritis Mechanism of TLR4 Inhibitors. ACS Omega. 2024 Aug 14;9(34):36232-36241. [Content Brief]

Keywords:

TLR4-IN-1