2. Anti-infection Cell Cycle/DNA Damage
  3. HIV DNA/RNA Synthesis
  4. 2738376-80-0

2738376-80-0

Prostaglandin J2-d<sub>4</sub> Chemical Structure

2738376-80-0

Chemical Structure

  • Prostaglandin J2-d4
  • CAS No: 2738376-80-0
    Formula: C20H26D4O4
    Molecular Weight: 338.47
  • IUPAC Name: (Z)-7-((1S,5R)-5-((S,E)-3-hydroxyoct-1-en-1-yl)-4-oxocyclopent-2-en-1-yl)hept-5-enoic-3,3,4,4-d4 acid
  • InChIKey: UQOQENZZLBSFKO-KREVBJNISA-N
  • SMILES: CCCCC[C@@H](/C=C/[C@@H]1[C@H](C=CC1=O)C/C=C\C([2H])(C([2H])(CC(O)=O)[2H])[2H])O

Biological Activity: Prostaglandin J2-d4 is the deuterium labeled Prostaglandin J2[1].

Cat. No. Product Name Purity Description
HY-113366S Prostaglandin J2-d4 Prostaglandin J2-d4 is the deuterium labeled Prostaglandin J2.
HY-113366 Prostaglandin J2 98.10% Prostaglandin J2 (PGJ2), an endogenous metabolite of Prostaglandin D2 (PGD2; HY-101988), is a potent PGD2 receptor (DP) agonist with Kis of 0.9 nM and 6.6 nM for hDP and hCRTH2, respectively. Prostaglandin J2 stimulates intracellular cyclic AMP production with an EC50 value of 1.2 nM. Prostaglandin J2 induces oxidative stress and neuronal apoptosis. Prostaglandin J2 induces the accumulation/aggregation of ubiquitinated (Ub) proteins. Prostaglandin J2 is highly neurotoxic and potentially contributes to many neurodegenerative conditions, including Alzheimer's (AD) and Parkinson's diseases (PD).

Keywords:

Prostaglandin J2-d4Prostaglandin J2