2. Immunology/Inflammation Apoptosis
  3. IRAK Apoptosis
  4. 2626988-86-9

2626988-86-9

IRAK4-IN-27 Chemical Structure

2626988-86-9

Chemical Structure

  • IRAK4-IN-27
  • CAS No: 2626988-86-9
    Formula: C23H22N6O3
    Molecular Weight: 430.46
  • InChIKey: OYRHXSCBISAPLC-UHFFFAOYSA-N
  • SMILES: O=C(C1=COC(C2=CC(N)=NC=C2)=N1)NC3=C(C4=CN(C)N=C4)C=C(OC(C)(C)C5)C5=C3

Biological Activity: IRAK4-IN-27 (Compound 22) is a potent, selective inhibitor of IRAK4, with IC50 of 8.7 nM. IRAK4-IN-27 inhibits cell growth, and promotes apoptosis in MYD88 L265P diffuse large B-cell lymphoma (DLBCL) cell line. IRAK4-IN-27 can be used for DLBCL study[1].

Cat. No. Product Name Purity Description
HY-155574 IRAK4-IN-27 IRAK4-IN-27 (Compound 22) is a potent, selective inhibitor of IRAK4, with IC50 of 8.7 nM. IRAK4-IN-27 inhibits cell growth, and promotes apoptosis in MYD88 L265P diffuse large B-cell lymphoma (DLBCL) cell line. IRAK4-IN-27 can be used for DLBCL study.

References

[1]. Chen Y, synthesis and pharmacological evaluation of 2,3-dihydrobenzofuran IRAK4 inhibitors for the treatment of diffuse large B-cell lymphoma. Eur J Med Chem. 2023;256:115453. [Content Brief]

Keywords:

IRAK4-IN-27