2. Immunology/Inflammation
  3. Interleukin Related
  4. 2648260-80-2

2648260-80-2

Rademikibart Chemical Structure

2648260-80-2

Chemical Structure

  • Rademikibart
  • Synonym(s): CBP-201
  • CAS No: 2648260-80-2
  • SMILES: [Rademikibart]

Biological Activity: Rademikibart (CBP-201) is a human monoclonal antibody targeting IL-4Rα with a KD of 20.7 pM when binding to human IL-4Rα epitopes. Rademikibart does not bind to IL-4Rα from other species. Rademikibart inhibits IL-4 and IL-13-mediated STAT6 signaling, TF-1 cell proliferation and TARC production in PBMCs. Rademikibart has the potential for moderate-to-severe Th2 inflammatory diseases research[1].

Cat. No. Product Name Purity Description
HY-P990090 Rademikibart 98.69% Rademikibart (CBP-201) is a human monoclonal antibody targeting IL-4Rα with a KD of 20.7 pM when binding to human IL-4Rα epitopes. Rademikibart does not bind to IL-4Rα from other species. Rademikibart inhibits IL-4 and IL-13-mediated STAT6 signaling, TF-1 cell proliferation and TARC production in PBMCs. Rademikibart has the potential for moderate-to-severe Th2 inflammatory diseases research.

References

[1]. Limin Zhang, et al. Preclinical immunological characterization of rademikibart (CBP-201), a next-generation human monoclonal antibody targeting IL-4Rα, for the treatment of Th2 inflammatory diseases. Sci Rep. 2023 Jul 31;13(1):12411. [Content Brief]

Keywords:

Rademikibart