2. Protein Tyrosine Kinase/RTK
  3. FLT3
  4. 2648799-49-7

2648799-49-7

FLT3/D835Y-IN-1 Chemical Structure

2648799-49-7

Chemical Structure

  • FLT3/D835Y-IN-1
  • CAS No: 2648799-49-7
    Formula: C22H21N5O3
    Molecular Weight: 403.43
  • IUPAC Name: (2Z,3E)-3-((2-oxo-2-(piperazin-1-yl)ethoxy)imino)-[2,3'-biindolinylidene]-2'-one
  • InChIKey: ROMHIQSFQAUVMM-OQBIKMBDSA-N
  • SMILES: O=C1NC2=C(C=CC=C2)/C1=C3NC4=C(C=CC=C4)C/3=N\OCC(N5CCNCC5)=O

Biological Activity: FLT3/D835Y-IN-1 (compound 13a) is a orally active, potent and selective FLT3 and FLT3/D835Y inhibitor, with IC50 values of 0.26 nM and 0.18 nM, respectively. FLT3/D835Y-IN-1 also blocks tumor growth, has anticancer efficacy, and can be used to research for AML (acute myeloid leukemia)[1].

Cat. No. Product Name Purity Description
HY-143434 FLT3/D835Y-IN-1 FLT3/D835Y-IN-1 (compound 13a) is a orally active, potent and selective FLT3 and FLT3/D835Y inhibitor, with IC50 values of 0.26 nM and 0.18 nM, respectively. FLT3/D835Y-IN-1 also blocks tumor growth, has anticancer efficacy, and can be used to research for AML (acute myeloid leukemia).

References

[1]. Lee JH, Shin JE, Kim W, et al. Discovery of indirubin-3'-aminooxy-acetamide derivatives as potent and selective FLT3/D835Y mutant kinase inhibitors for acute myeloid leukemia. Eur J Med Chem. 2022 Apr 21;237:114356. [Content Brief]

Keywords:

FLT3/D835Y-IN-1