2. Cell Cycle/DNA Damage
  3. CDK
  4. 2649120-22-7

2649120-22-7

CDK4/6-IN-8 Chemical Structure

2649120-22-7

Chemical Structure

  • CDK4/6-IN-8
  • CAS No: 2649120-22-7
    Formula: C18H18N6O5
    Molecular Weight: 398.37
  • IUPAC Name: (R)-1-(2-(4-nitrobenzoyl)hydrazine-1-carbonyl)-N-(pyridin-3-yl)pyrrolidine-2-carboxamide
  • InChIKey: CPWNIEDXLMGOJD-OAHLLOKOSA-N
  • SMILES: O=C(C1=CC=C([N+]([O-])=O)C=C1)NNC(N2CCC[C@@H]2C(NC3=CC=CN=C3)=O)=O

Biological Activity: CDK4/6-IN-8 (Compound 7p) is a selective CDK4 and CDK6 inhibitor with IC50 values of 5.01 nM and 3.97 nM, respectively[1].

Cat. No. Product Name Purity Description
HY-143258 CDK4/6-IN-8 CDK4/6-IN-8 (Compound 7p) is a selective CDK4 and CDK6 inhibitor with IC50 values of 5.01 nM and 3.97 nM, respectively.

References

[1]. Liang JW, et al. Synthesis and identification of a novel skeleton of N-(pyridin-3-yl) proline as a selective CDK4/6 inhibitor with anti-breast cancer activities. Bioorg Chem. 2022 Feb;119:105547. [Content Brief]

Keywords:

CDK4/6-IN-8