2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. 919936-70-2

919936-70-2

GS87 Chemical Structure

919936-70-2

Chemical Structure

  • GS87
  • CAS No: 919936-70-2
    Formula: C16H11N5O2S
    Molecular Weight: 337.36
  • IUPAC Name: 3-phenyl-5-(((5-(pyridin-4-yl)-1,3,4-oxadiazol-2-yl)thio)methyl)-1,2,4-oxadiazole
  • InChIKey: HNTUWEZDVRVSFY-UHFFFAOYSA-N
  • SMILES: C1(C2=NN=C(SCC3=NC(C4=CC=CC=C4)=NO3)O2)=CC=NC=C1

Biological Activity: GS87 is a highly specific and potent GSK3 inhibitor with IC50s of 415nM and 521nM for GSK3α and GSK3β, respectively. GS87 induces differentiation of acute myeloid leukemia (AML) cell lines by effectively activating GSK3-dependent signaling components including MAPK signaling. GS87 modulates key GSK3 target proteins involved in cell proliferation and differentiation more effectively than Lithium and SB415285 (SB). GS87 has the potential for acting as a differentiation agent for non-promyelocytic AML research[1].

Cat. No. Product Name Purity Description
HY-134557 GS87 GS87 is a highly specific and potent GSK3 inhibitor with IC50s of 415nM and 521nM for GSK3α and GSK3β, respectively. GS87 induces differentiation of acute myeloid leukemia (AML) cell lines by effectively activating GSK3-dependent signaling components including MAPK signaling. GS87 modulates key GSK3 target proteins involved in cell proliferation and differentiation more effectively than Lithium and SB415285 (SB). GS87 has the potential for acting as a differentiation agent for non-promyelocytic AML research.

References

[1]. Sophia Hu, et al. A Novel Glycogen Synthase Kinase-3 Inhibitor Optimized for Acute Myeloid Leukemia Differentiation Activity. Mol Cancer Ther. 2016 Jul;15(7):1485-1494. [Content Brief]

Keywords:

GS87