2. Others Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. Isotope-Labeled Compounds Progesterone Receptor Endogenous Metabolite
  4. 2760195-67-1

2760195-67-1

SYHA1815 Chemical Structure

2760195-67-1

Chemical Structure

  • SYHA1815
  • CAS No: 2760195-67-1
    Formula: C27H26ClF4N5O
    Molecular Weight: 547.97
  • InChIKey: SWMFIGMUMWFQHQ-UHFFFAOYSA-N
  • SMILES: CN(CC1)CCN1CC2=C(C(F)(F)F)C=C(NC(C3=CC(F)=CC(C#CC4=CC=CN=C4N)=C3)=O)C=C2.Cl

Biological Activity: SYHA1815 is an orally active RET inhibitor (IC50=0.9 nmol/L) with antitumor activity. SYHA1815 is more selective for RET than KDR (IC50=15.9 nmol/L). SYHA1815 arrests the G1 cell cycle and inhibits RET-driven cell proliferation by downregulating c-Myc[1].

Cat. No. Product Name Purity Description
HY-149451 SYHA1815 SYHA1815 is an orally active RET inhibitor (IC50=0.9 nmol/L) with antitumor activity. SYHA1815 is more selective for RET than KDR (IC50=15.9 nmol/L). SYHA1815 arrests the G1 cell cycle and inhibits RET-driven cell proliferation by downregulating c-Myc.

References

[1]. Yuchen Jiang, et al. "The novel RET inhibitor SYHA1815 inhibits RET-driven cancers and overcomes gatekeeper mutations by inducing G1 cell-cycle arrest through c-myc downregulation." Molecular Cancer Therapeutics 20.11 (2021): 2198-2206. [Content Brief]

Keywords:

SYHA1815