2. Epigenetics PROTAC
  3. Histone Methyltransferase PROTACs
  4. 2688842-08-0

2688842-08-0

UNC6852 Chemical Structure

2688842-08-0

Chemical Structure

  • UNC6852
  • CAS No: 2688842-08-0
    Formula: C43H48N10O6S
    Molecular Weight: 832.97
  • IUPAC Name: (2S,4R)-1-((S)-2-(4-(4-(5-((furan-2-ylmethyl)amino)-[1,2,4]triazolo[4,3-c]pyrimidin-8-yl)benzamido)butanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
  • InChIKey: PPNNFXIBKLCMTI-WXEAQWFJSA-N
  • SMILES: O=C(C1=CC=C(C=C1)C2=CN=C(N3C2=NN=C3)NCC4=CC=CO4)NCCCC(N[C@H](C(N5[C@@H](C[C@H](C5)O)C(NCC6=CC=C(C=C6)C7=C(N=CS7)C)=O)=O)C(C)(C)C)=O

Biological Activity: UNC6852 is a selective polycomb repressive complex 2 (PRC2) degrader based on PROTAC and contains an EED (embryonic ectoderm development) ligand and a von Hippel-Lindau ligand, with an IC50 of 247 nM for EED[1].

Cat. No. Product Name Purity Description
HY-130708 UNC6852 99.60% UNC6852 is a selective polycomb repressive complex 2 (PRC2) degrader based on PROTAC and contains an EED (embryonic ectoderm development) ligand and a von Hippel-Lindau ligand, with an IC50 of 247 nM for EED.

References

[1]. Potjewyd F, et al. Degradation of Polycomb Repressive Complex 2 with an EED-Targeted Bivalent Chemical Degrader. Cell Chem Biol. 2020 Jan 16;27(1):47-56.e15. [Content Brief]

Keywords:

UNC6852