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  4. 3033645-28-9

3033645-28-9

Chitin synthase inhibitor 5 Chemical Structure

3033645-28-9

Chemical Structure

  • Chitin synthase inhibitor 5
  • CAS No: 3033645-28-9
    Formula: C23H22BrN3O5
    Molecular Weight: 500.34
  • IUPAC Name: (E)-N-(4-bromophenyl)-4-(6-methoxy-2-oxo-1,2-dihydrospiro[benzo[d][1,3]oxazine-4,4'-piperidin]-1'-yl)-4-oxobut-2-enamide
  • InChIKey: OGFJSCZAUVWZAU-CMDGGOBGSA-N
  • SMILES: COC1=CC2=C(NC(OC23CCN(CC3)C(/C=C/C(NC4=CC=C(C=C4)Br)=O)=O)=O)C=C1

Biological Activity: Chitin synthase inhibitor 5 (compound 9a) is an inhibitor of chitin synthase with an IC50 value of 0.14 mM. Chitin synthase inhibitor 5 shows broad-spectrum antifungal activity in vitro and shows good inhibition to C. albicans, A. flavus, A. fumigatus and C. neoformans. Chitin synthase inhibitor 5 can be used for the research of fungal[1].

References

[1]. Xu Y, et al. Spiro[benzoxazine-piperidin]-one derivatives as chitin synthase inhibitors and antifungal agents: Design, synthesis and biological evaluation. Eur J Med Chem. 2022 Aug 31;243:114723. [Content Brief]

Keywords:

Chitin synthase inhibitor 5