2243207-08-9

Chemical Structure

[Ala2] Endothelin-3, human
CAS No: 2243207-08-9

Formula: C₁₂₀H₁₆₆N₂₆O₃₂S₄

Molecular Weight: 2613.02
SMILES: O=C([C@@H](N)CSSC[C@H](NC1=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CC2=CNC3=CC=CC=C23)=O)[C@H](CC)C)=O)[C@H](CC)C)=O)CC(O)=O)=O)CC(C)C)=O)CC4=CNC=N4)=O)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]5CCC(O)=O)=O)CCCCN)=O)CC(O)=O)=O)CCCCN)=O)CC6=CC=C(O)C=C6)=O)[C@@H](C)O)=O)CC7=CC=CC=C7)=O)CSSC[C@H](NC5=O)C(N[C@H](C(N[C@H](C(N[C@H]1CC8=CC=C(O)C=C8)=O)CC9=CC=C(O)C=C9)=O)C(C)C)=O)=O)C

Biological Activity: [Ala2] Endothelin-3, human is a linear analog of endothelin-3 (ET-3) where substitution of Ala for Cys residues. TE-3 is a vasoactive peptide, produced by human rhabdomyosarcoma cell lines, whereas it is not expressed by human sarcoma cell lines of non-muscle origin. ET-3 acts as a paracrine factor, since it promotes migration of endothelial cells^[1]^[2].

Cat. No.	Product Name	Purity	Description
HY-P3571	[Ala2] Endothelin-3, human		[Ala2] Endothelin-3, human is a linear analog of endothelin-3 (ET-3) where substitution of Ala for Cys residues. TE-3 is a vasoactive peptide, produced by human rhabdomyosarcoma cell lines, whereas it is not expressed by human sarcoma cell lines of non-muscle origin. ET-3 acts as a paracrine factor, since it promotes migration of endothelial cells.

References

[1]. Palladini A, et al. Endothelin-3 production by human rhabdomyosarcoma: a possible new marker with a paracrine role. Eur J Cancer. 2006 Mar;42(5):680-7. [Content Brief]
[2]. Davenport AP, et al. Endothelin. Pharmacol Rev. 2016 Apr;68(2):357-418.

Keywords:

[Ala2] Endothelin-3, human

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