2. Cell Cycle/DNA Damage PI3K/Akt/mTOR
  3. DNA-PK
  4. 2711810-41-0

2711810-41-0

DNA-PK-IN-6 Chemical Structure

2711810-41-0

Chemical Structure

  • DNA-PK-IN-6
  • CAS No: 2711810-41-0
    Formula: C19H21N7O
    Molecular Weight: 363.42
  • IUPAC Name: (12E,35E)-17,37-dimethyl-13,17,18,19-tetrahydro-12H-2-aza-1(2,9)-purina-3(6,3)-imidazo[1,2-a]pyridinacyclooctaphan-18-one
  • InChIKey: DXOSNFFQQVJOOZ-UHFFFAOYSA-N
  • SMILES: O=C1N(C)C2=C(N3)N1CCCCCC4=CN=C(C=C5C)N4C=C5/N=C3/N=C2

Biological Activity: DNA-PK-IN-6 is a potent inhibitor of DNA-PK. DNA-PK-IN-6 inhibits DNA-PKcs activity, thus greatly reducing tumor DNA repair and inducing cells to enter the apoptotic program. DNA-PK-IN-6 enhances the sensitivity of tumor tissues to radiotherapy, overcomes the problem of agent resistance, and enhances the inhibitory effect on a variety of solid tumors and hematological tumors (extracted from patent WO2021197159A1, compound 6)[1].

Cat. No. Product Name Purity Description
HY-144039 DNA-PK-IN-6 DNA-PK-IN-6 is a potent inhibitor of DNA-PK. DNA-PK-IN-6 inhibits DNA-PKcs activity, thus greatly reducing tumor DNA repair and inducing cells to enter the apoptotic program. DNA-PK-IN-6 enhances the sensitivity of tumor tissues to radiotherapy, overcomes the problem of agent resistance, and enhances the inhibitory effect on a variety of solid tumors and hematological tumors (extracted from patent WO2021197159A1, compound 6).

References

[1]. Xinhai Chen, et al. Macrocyclic compounds as dna-pk inhibitors. Patent WO2021197159A1.

Keywords:

DNA-PK-IN-6