2. Anti-infection Cell Cycle/DNA Damage
  3. HBV DNA/RNA Synthesis
  4. 1354955-67-1

1354955-67-1

GNE-293 Chemical Structure

1354955-67-1

Chemical Structure

  • GNE-293
  • CAS No: 1354955-67-1
    Formula: C28H36N8O4S
    Molecular Weight: 580.70
  • IUPAC Name: 4-(3-((2-(2-isopropyl-1H-benzo[d]imidazol-1-yl)-9-methyl-6-morpholino-9H-purin-8-yl)oxy)azetidin-1-yl)tetrahydro-2H-thiopyran 1,1-dioxide
  • InChIKey: XRLOEZGWBZHADC-UHFFFAOYSA-N
  • SMILES: CC(C)C1=NC(C=CC=C2)=C2N1C3=NC4=C(N=C(OC5CN(C6CCS(CC6)(=O)=O)C5)N4C)C(N7CCOCC7)=N3

Biological Activity: GNE-293 is a potent and selective PI3Kδ inhibitor (IC50 = 4.38 nM). GNE-293 has favorable pharmacokinetic properties. GNE-293 can be used for research of asthma, rheumatoid arthritis, and other inflammatory disorders[1].

Cat. No. Product Name Purity Description
HY-12517 GNE-293 GNE-293 is a potent and selective PI3Kδ inhibitor (IC50 = 4.38 nM). GNE-293 has favorable pharmacokinetic properties. GNE-293 can be used for research of asthma, rheumatoid arthritis, and other inflammatory disorders.

References

[1]. Safina BS, et al. Identification of GNE-293, a potent and selective PI3Kδ inhibitor: navigating in vitro genotoxicity while improving potency and selectivity. Bioorg Med Chem Lett. 2013 Sep 1;23(17):4953-9. [Content Brief]

Keywords:

GNE-293