2. Protein Tyrosine Kinase/RTK
  3. FGFR
  4. 2417955-18-9

2417955-18-9

Osivelotor Chemical Structure

2417955-18-9

Chemical Structure

  • Osivelotor
  • Synonym(s): GBT-601; GBT-021601
  • CAS No: 2417955-18-9
    Formula: C20H22N2O6
    Molecular Weight: 386.40
  • IUPAC Name: (S)-2-hydroxy-6-((4-(2-(2-hydroxyethyl)nicotinoyl)morpholin-3-yl)methoxy)benzaldehyde
  • InChIKey: NIWBSQAKKNNWBT-AWEZNQCLSA-N
  • SMILES: O=C(C1=C(N=CC=C1)CCO)N2[C@@H](COCC2)COC3=C(C(O)=CC=C3)C=O

Biological Activity: Osivelotor is an orally effective small molecule. Osivelotor is an allosteric regulator of deoxyhemoglobin S (HbS). Osivelotor increases the affinity of HbS to oxygen, inhibits HbS polymerization, and thus prevents erythrocyte sickling in the blood. Osivelotor can be used for research of sickle cell disease (SCD) [1] [2].

Cat. No. Product Name Purity Description
HY-148788 Osivelotor 99.83% Osivelotor is an orally effective small molecule. Osivelotor is an allosteric regulator of deoxyhemoglobin S (HbS). Osivelotor increases the affinity of HbS to oxygen, inhibits HbS polymerization, and thus prevents erythrocyte sickling in the blood. Osivelotor can be used for research of sickle cell disease (SCD) .

References

[1]. WHO Drug Information-World Health Organization (WHO).
[2]. Dufu K, et al. GBT021601 improves red blood cell health and the pathophysiology of sickle cell disease in a murine model. Br J Haematol. 2023 Jul;202(1):173-183. [Content Brief]

Keywords:

Osivelotor