2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. 2765294-54-8

2765294-54-8

TRPV1 antagonist 3 Chemical Structure

2765294-54-8

Chemical Structure

  • TRPV1 antagonist 3
  • CAS No: 2765294-54-8
    Formula: C23H25N3OS
    Molecular Weight: 391.53
  • IUPAC Name: (S)-N-(3-isopropylphenyl)-2-(5-phenylthiazol-2-yl)pyrrolidine-1-carboxamide
  • InChIKey: CZISSZWUQQBGMU-FQEVSTJZSA-N
  • SMILES: CC(C1=CC=CC(NC(N2CCC[C@H]2C3=NC=C(S3)C4=CC=CC=C4)=O)=C1)C

Biological Activity: TRPV1 antagonist 3 (Compound 7q) is a potent TRPV1 antagonist with an IC50 of 2.66 nM against capsaicin. TRPV1 antagonist 3 is mode-selective, oral bioavailable (F = 60%) and CNS-penetrant[1].

Cat. No. Product Name Purity Description
HY-144372 TRPV1 antagonist 3 99.30% TRPV1 antagonist 3 (Compound 7q) is a potent TRPV1 antagonist with an IC50 of 2.66 nM against capsaicin. TRPV1 antagonist 3 is mode-selective, oral bioavailable (F = 60%) and CNS-penetrant.

References

[1]. Yue Qiao, et al. Discovery of (S)-N-(3-isopropylphenyl)-2-(5-phenylthiazol-2-yl)pyrrolidine-1-carboxamide as potent and brain-penetrant TRPV1 antagonist. Eur J Med Chem. 2022 Apr 5;233:114191. [Content Brief]

Keywords:

TRPV1 antagonist 3