2. Vitamin D Related/Nuclear Receptor
  3. Estrogen Receptor/ERR
  4. 2768139-76-8

2768139-76-8

ErSO-DFP Chemical Structure

2768139-76-8

Chemical Structure

  • ErSO-DFP
  • CAS No: 2768139-76-8
    Formula: C20H17F5N2O2
    Molecular Weight: 412.35
  • IUPAC Name: (R)-3-(4,4-difluoropiperidin-1-yl)-3-(4-hydroxyphenyl)-7-(trifluoromethyl)indolin-2-one
  • InChIKey: IVIIASPFEXRZGM-LJQANCHMSA-N
  • SMILES: O=C1NC2=C(C=CC=C2[C@]1(N3CCC(F)(CC3)F)C4=CC=C(C=C4)O)C(F)(F)F

Biological Activity: ErSO-DFP is an anticipatory unfolded protein response (a-UPR) activator. ErSO-DFP has enhanced selectivity for estrogen receptor alpha-positive (ERα+) cancer cells with a wider selectivity window than ErSO.ErSO-DFP displays antitumor activity and leads to profound regression of MCF-7 tumors in mice model[1].

Cat. No. Product Name Purity Description
HY-144070 ErSO-DFP 99.56% ErSO-DFP is an anticipatory unfolded protein response (a-UPR) activator. ErSO-DFP has enhanced selectivity for estrogen receptor alpha-positive (ERα+) cancer cells with a wider selectivity window than ErSO.ErSO-DFP displays antitumor activity and leads to profound regression of MCF-7 tumors in mice model.

References

[1]. Matthew W Boudreau, et al. Activators of the Anticipatory Unfolded Protein Response with Enhanced Selectivity for Estrogen Receptor Positive Breast Cancer. J Med Chem. 2022 Mar 10;65(5):3894-3912. [Content Brief]

Keywords:

ErSO-DFP