2. Epigenetics
  3. Epigenetic Reader Domain
  4. 1101848-34-3

1101848-34-3

RdRP-IN-9 Chemical Structure

1101848-34-3

Chemical Structure

  • RdRP-IN-9
  • CAS No: 1101848-34-3
    Formula: C19H21NO5
    Molecular Weight: 343.37
  • SMILES: [H][C@@]12[C@](C3=C[C@H](O)[C@H]2OC(CC)=O)([H])N(CC3)CC4=CC5=C(OCO5)C=C41

Biological Activity: RdRP-IN-9 (Compound 6b) is a reversible covalent allosteric inhibitor of RdRp. RdRP-IN-9 demonstrates high anti-coronavirus activity, with an EC50 value of 0.68 μM against HCoV-OC43 RdRP-IN-9 exerts a more prolonged antiviral effect by reversibly acylating Cys12 in the NiRAN domain of non-structural protein 12 (nsp 12) and exhibits synergistic anti-coronavirus activity with Molnupiravir (HY-135853) [1].

Cat. No. Product Name Purity Description
HY-170649 RdRP-IN-9 RdRP-IN-9 (Compound 6b) is a reversible covalent allosteric inhibitor of RdRp. RdRP-IN-9 demonstrates high anti-coronavirus activity, with an EC50 value of 0.68 μM against HCoV-OC43 RdRP-IN-9 exerts a more prolonged antiviral effect by reversibly acylating Cys12 in the NiRAN domain of non-structural protein 12 (nsp 12) and exhibits synergistic anti-coronavirus activity with Molnupiravir (HY-135853) .

References

[1]. Mei Y, et al. Lycorine esters exert anti-HCoV-OC43 effect through reversibly acylating cysteine residue in the nsp 12 NiRAN domain[J]. Bioorganic Chemistry, 2024: 108086. [Content Brief]

Keywords:

RdRP-IN-9