2. Metabolic Enzyme/Protease
  3. 17β-HSD
  4. 1622917-95-6

1622917-95-6

TH152 Chemical Structure

1622917-95-6

Chemical Structure

  • TH152
  • CAS No: 1622917-95-6
    Formula: C22H23ClN4O4S2
    Molecular Weight: 507.03
  • InChIKey: LWPNKRYFNXAWGF-UHFFFAOYSA-N
  • SMILES: OC(C1=CC=C(C=C1)C2=CSC(NC3=CC(Cl)=NC(SC(CCCCCC)C(O)=O)=N3)=N2)=O

Biological Activity: TH152 is a reversible, pan ligand for LC3/GABARAP with a KD of 2 µM. LC3/GABARAP is an autophagy associated protein[1].

Cat. No. Product Name Purity Description
HY-132195 RORγt inverse agonist 14 RORγt inverse agonist 14 (8e) is a potent, orally active and selective RORγt inverse agonist (EC50 of 2.5 nM) with anti-inflammatory activity. RORγt inverse agonist 14 is used in the study for rheumatoid arthritis and psoriasis.

References

[1]. Schwalm MP, et al., Critical assessment of LC3/GABARAP ligands used for degrader development and ligandability of LC3/GABARAP binding pockets. Nat Commun. 2024 Nov 25;15(1):10204. [Content Brief]

Keywords:

TH152