2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. 1553977-42-6

1553977-42-6

IBT6A hydrochloride Chemical Structure

1553977-42-6

Chemical Structure

  • IBT6A hydrochloride
  • CAS No: 1553977-42-6
    Formula: C22H23ClN6O
    Molecular Weight: 422.91
  • IUPAC Name: (R)-3-(4-phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine hydrochloride
  • InChIKey: ATLAMSZMAHXMSQ-PKLMIRHRSA-N
  • SMILES: NC1=C2C(N([C@H]3CNCCC3)N=C2C4=CC=C(OC5=CC=CC=C5)C=C4)=NC=N1.Cl

Biological Activity: IBT6A hydrochloride is an impurity of Ibrutinib. IBT6A can be used in synthesis of IBT6A Ibrutinib dimer and IBT6A adduct[1]. Ibrutinib is a selective, irreversible Btk inhibitor with an IC50 of 0.5 nM[2].

Cat. No. Product Name Purity Description
HY-13036B IBT6A hydrochloride 99.72% IBT6A hydrochloride is an impurity of Ibrutinib. IBT6A can be used in synthesis of IBT6A Ibrutinib dimer and IBT6A adduct. Ibrutinib is a selective, irreversible Btk inhibitor with an IC50 of 0.5 nM.

References

[1]. Somana Siva Prasad, et al. A QUALITY BY DESIGN APPROACH FOR DEVELOPMENT OF SIMPLE AND ROBUST REVERSED PHASE STABILITY INDICATING HPLC METHOD FOR ESTIMATION OF IBRUTINIB AND ITS IMPURITIES.
[2]. Honigberg LA, et al. The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13075-80. [Content Brief]

Keywords:

IBT6A hydrochloride