2. PROTAC Vitamin D Related/Nuclear Receptor
  3. PROTACs Estrogen Receptor/ERR
  4. 2758364-02-0

2758364-02-0

CAM833 Chemical Structure

2758364-02-0

Chemical Structure

  • CAM833
  • CAS No: 2758364-02-0
    Formula: C26H26ClFN4O5
    Molecular Weight: 528.96
  • IUPAC Name: N-(2-((2S,4R)-2-(((S)-1-(2-chloro-4-methoxyphenyl)ethyl)carbamoyl)-4-hydroxypyrrolidin-1-yl)-2-oxoethyl)-6-fluoroquinoline-2-carboxamide
  • InChIKey: PMUWBFKMLGLUTF-KNUWZQJKSA-N
  • SMILES: C[C@@H](C1=C(C=C(C=C1)OC)Cl)NC([C@H]2N(C[C@@H](C2)O)C(CNC(C3=NC4=C(C=C(C=C4)F)C=C3)=O)=O)=O

Biological Activity: CAM833 is a potent orthosteric inhibitor of the interaction between BRCA2 and RAD51 with a Kd of 366 nM against the ChimRAD51 protein. CAM833 also inhibits RAD51 oligomerization. CAM833 increases the progression of G2/M-arrested cells into apoptosis[1].

Cat. No. Product Name Purity Description
HY-150147 CAM833 99.83% CAM833 is a potent orthosteric inhibitor of the interaction between BRCA2 and RAD51 with a Kd of 366 nM against the ChimRAD51 protein. CAM833 also inhibits RAD51 oligomerization. CAM833 increases the progression of G2/M-arrested cells into apoptosis.

References

[1]. Scott DE, et al. A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death. Cell Chem Biol. 2021 Jun 17;28(6):835-847.e5. [Content Brief]

Keywords:

CAM833