2. GPCR/G Protein Neuronal Signaling
  3. Somatostatin Receptor
  4. 2851454-42-5

2851454-42-5

SSTR5 antagonist 3 Chemical Structure

2851454-42-5

Chemical Structure

  • SSTR5 antagonist 3
  • CAS No: 2851454-42-5
    Formula: C31H36F2N2O5
    Molecular Weight: 554.62
  • InChIKey: XFYGZKXJXFGWPA-UHFFFAOYSA-N
  • SMILES: FC1=CC=C(C2=C(C=C(C=C2OCC)CN3CCC(F)(CC3)CNC4=CC(OC)=C(C(O)=O)C=C4)OCC)C=C1

Biological Activity: SSTR5 antagonist 3 (Compound 23) is an orally active somatostatin receptor subtype 5 (SSTR5) antagonist with low hERG inhibition. SSTR5 antagonist 3 exhibits potency with IC50 values of 2.8 nM and 1.4 nM in human and mouse, respectively. SSTR5 antagonist 3 can be used for the research of anti-gallstone[1].

Cat. No. Product Name Purity Description
HY-157303 SSTR5 antagonist 3 SSTR5 antagonist 3 (Compound 23) is an orally active somatostatin receptor subtype 5 (SSTR5) antagonist with low hERG inhibition. SSTR5 antagonist 3 exhibits potency with IC50 values of 2.8 nM and 1.4 nM in human and mouse, respectively. SSTR5 antagonist 3 can be used for the research of anti-gallstone.

References

[1]. Han F, et al. Discovery and exploration of novel somatostatin receptor subtype 5 (SSTR5) antagonists for the treatment of cholesterol gallstones. Eur J Med Chem. 2023 Dec 5;264:116017. [Content Brief]

Keywords:

SSTR5 antagonist 3