2. Neuronal Signaling
  3. Sigma Receptor
  4. 1047634-65-0

1047634-65-0

Uprosertib Chemical Structure

1047634-65-0

Chemical Structure

  • Uprosertib
  • Synonym(s): GSK2141795
  • CAS No: 1047634-65-0
    Formula: C18H16Cl2F2N4O2
    Molecular Weight: 429.25
  • IUPAC Name: (S)-N-(1-amino-3-(3,4-difluorophenyl)propan-2-yl)-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)furan-2-carboxamide
  • InChIKey: AXTAPYRUEKNRBA-JTQLQIEISA-N
  • SMILES: O=C(C1=CC(C2=C(Cl)C=NN2C)=C(Cl)O1)N[C@@H](CC3=CC=C(F)C(F)=C3)CN

Biological Activity: Uprosertib (GSK2141795) is a potent and selective pan-Akt inhibitor with IC50 values of 180/328/38 nM for Akt1/Akt2/Akt3, respectively.

Cat. No. Product Name Purity Description
HY-155111 nSMase2-IN-1 98.24% nSMase2-IN-1 is an orally active Neutral sphingomyelinase 2 (nSMase2) inhibitor with an IC50 value of 0.13 ± 0.06 μM. nSMase2-IN-1 is metabolically stable in liver microsomes and orally available with a favorable brain-to-plasma ratio. nSMase2-IN-1 can be used for nervous system disease research.

Keywords:

Uprosertib