2. Apoptosis Metabolic Enzyme/Protease
  3. Apoptosis Carbonic Anhydrase Phosphodiesterase (PDE)
  4. 2883495-39-2

2883495-39-2

Enpp/Carbonic anhydrase-IN-2 Chemical Structure

2883495-39-2

Chemical Structure

  • Enpp/Carbonic anhydrase-IN-2
  • CAS No: 2883495-39-2
    Formula: C23H24FNO4S
    Molecular Weight: 429.50
  • IUPAC Name: 4-(adamantane-1-carboxamido)phenyl 4-fluorobenzenesulfonate
  • InChIKey: LLXLLGJJXOHBLG-UHFFFAOYSA-N
  • SMILES: O=C(C12CC3CC(C2)CC(C1)C3)NC4=CC=C(C=C4)OS(=O)(C5=CC=C(C=C5)F)=O

Biological Activity: Enpp/Carbonic anhydrase-IN-2 (compound 1i) is a potent Enpp and carbonic anhydrase inhibitor with IC50s of 1.13, 1.07, 0.74, 0.33, 0.68 for NPP1, NPP2, NPP3, CA-IX, CA-XII respectively. Enpp/Carbonic anhydrase-IN-2 shows antiproliferative activity for cancer cells and low cytotoxic against normal cells. Enpp/Carbonic anhydrase-IN-2 induces Apoptosis[1].

Cat. No. Product Name Purity Description
HY-151917 Enpp/Carbonic anhydrase-IN-2 99.76% Enpp/Carbonic anhydrase-IN-2 (compound 1i) is a potent Enpp and carbonic anhydrase inhibitor with IC50s of 1.13, 1.07, 0.74, 0.33, 0.68 for NPP1, NPP2, NPP3, CA-IX, CA-XII respectively. Enpp/Carbonic anhydrase-IN-2 shows antiproliferative activity for cancer cells and low cytotoxic against normal cells. Enpp/Carbonic anhydrase-IN-2 induces Apoptosis.

References

[1]. Afnan I.Shahin, et al. Design and synthesis of new adamantyl derivatives as promising antiproliferative agents. European Journal of Medicinal Chemistry, 2022.

Keywords:

Enpp/Carbonic anhydrase-IN-2