2. PI3K/Akt/mTOR
  3. PI3K
  4. 2893920-80-2

2893920-80-2

PI3Kα-IN-15 Chemical Structure

2893920-80-2

Chemical Structure

  • PI3Kα-IN-15
  • CAS No: 2893920-80-2
    Formula: C25H24FN5O4S
    Molecular Weight: 509.55
  • InChIKey: WJYGISBEERSANC-UHFFFAOYSA-N
  • SMILES: O=S(C1=CC=C(F)C=C1)(NC2=CC(C3=CC(C)=CN4C3=NC(C(N5CCCC5)=O)=C4)=CN=C2OC)=O

Biological Activity: PI3Kα-IN-15 is a potent PI3Kα inhibitor with an IC50 of 0.15?μM. PI3Kα-IN-15 also has acceptable anti-proliferative activity (inhibits SKOV-3, T47D, NCI-H1975, NCI-H460, and MCF-7 growth with IC50 values of 26.6?μM, 7.9?μM,? 32.1?μM,? 17.7??μM, and 9.4??μM, respectively. PI3Kα-IN-15 can be used for cancer research[1].

Cat. No. Product Name Purity Description
HY-157319 PI3Kα-IN-15 PI3Kα-IN-15 is a potent PI3Kα inhibitor with an IC50 of 0.15?μM. PI3Kα-IN-15 also has acceptable anti-proliferative activity (inhibits SKOV-3, T47D, NCI-H1975, NCI-H460, and MCF-7 growth with IC50 values of 26.6?μM, 7.9?μM,? 32.1?μM,? 17.7??μM, and 9.4??μM, respectively. PI3Kα-IN-15 can be used for cancer research.

References

[1]. Rui Chen, et al. Design, synthesis and evaluation of 2, 6, 8-substituted Imidazopyridine derivatives as potent PI3K α inhibitors. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2155638. [Content Brief]

Keywords:

PI3Kα-IN-15