2. GPCR/G Protein
  3. CRFR
  4. 3031654-46-0

3031654-46-0

NC-III-49-1 Chemical Structure

3031654-46-0

Chemical Structure

  • NC-III-49-1
  • CAS No: 3031654-46-0
    Formula: C44H50N4O11S2
    Molecular Weight: 875.02
  • IUPAC Name: N,N'-(((((oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl))bis(oxy))bis(3-(2-methyl-1-oxo-1,2-dihydroisoquinolin-4-yl)-4,1-phenylene))diethanesulfonamide
  • InChIKey: VGOFJMULWAVDMV-UHFFFAOYSA-N
  • SMILES: CCS(=O)(NC1=CC=C(C(C(C2=C3C=CC=C2)=CN(C3=O)C)=C1)OCCOCCOCCOCCOC4=CC=C(C=C4C(C5=C6C=CC=C5)=CN(C6=O)C)NS(CC)(=O)=O)=O

Biological Activity: NC-III-49-1 is a potent bivalent bromodomain and extraterminal domain (BET) inhibitor. NC-III-49-1 shows binding potential for BRD4-1, BRD4-2, BRD4-T, BRDT-1, BRDT-2, BRDT-T with Kd values of 0.095, 0.32, 0.29, 0.089, 5.5, 0.058 nM, respectively. NC-III-49-1 shows antiproliferative activity. NC-III-49-1 decreases the expression of c-Myc[1].

Cat. No. Product Name Purity Description
HY-150683 NC-III-49-1 NC-III-49-1 is a potent bivalent bromodomain and extraterminal domain (BET) inhibitor. NC-III-49-1 shows binding potential for BRD4-1, BRD4-2, BRD4-T, BRDT-1, BRDT-2, BRDT-T with Kd values of 0.095, 0.32, 0.29, 0.089, 5.5, 0.058 nM, respectively. NC-III-49-1 shows antiproliferative activity. NC-III-49-1 decreases the expression of c-Myc.

References

[1]. Guan X, et al. Bivalent BET Bromodomain Inhibitors Confer Increased Potency and Selectivity for BRDT via Protein Conformational Plasticity. J Med Chem. 2022 Jul 22. [Content Brief]

Keywords:

NC-III-49-1