2. Metabolic Enzyme/Protease
  3. FXR
  4. 1224678-75-4

1224678-75-4

653-47 Chemical Structure

1224678-75-4

Chemical Structure

  • 653-47
  • CAS No: 1224678-75-4
    Formula: C20H19ClN2O3
    Molecular Weight: 370.83
  • IUPAC Name: 3-(3-aminopropoxy)-N-(4-chloro-2-hydroxyphenyl)-2-naphthamide
  • InChIKey: MWSVLRCALWWDRV-UHFFFAOYSA-N
  • SMILES: O=C(C1=C(OCCCN)C=C2C=CC=CC2=C1)NC3=CC=C(Cl)C=C3O

Biological Activity: 653-47, a potentiator, significantly potentiates the cAMP-response element binding protein (CREB) inhibitory activity of 666-15. 653-47 is also a very weak CREB inhibitor with IC50 of 26.3 μM[1].

Cat. No. Product Name Purity Description
HY-134598 653-47 653-47, a potentiator, significantly potentiates the cAMP-response element binding protein (CREB) inhibitory activity of 666-15. 653-47 is also a very weak CREB inhibitor with IC50 of 26.3 μM.

References

[1]. Xie F, et al. Discovery of a Synergistic Inhibitor of cAMP-Response Element Binding Protein (CREB)-Mediated Gene Transcription with 666-15. J Med Chem. 2019;62(24):11423-11429. [Content Brief]

Keywords:

653-47