2. Cell Cycle/DNA Damage PI3K/Akt/mTOR Apoptosis
  3. ATM/ATR Apoptosis
  4. 3033712-80-7

3033712-80-7

ATM Inhibitor-7 Chemical Structure

3033712-80-7

Chemical Structure

  • ATM Inhibitor-7
  • CAS No: 3033712-80-7
    Formula: C27H28N6O
    Molecular Weight: 452.55
  • InChIKey: KAHMZYOZNYFPKN-LJQANCHMSA-N
  • SMILES: CN(C)CCCOC1=NC=C(C2=CC=C(N=CC3=C4N([C@H](C)C5=CC=CC=C5)N=N3)C4=C2)C=C1

Biological Activity: ATM Inhibitor-7 is a potent and selective ataxia-telangiectasia mutated (ATM) inhibitor with an IC50 value of 1.0 nM. ATM Inhibitor-7 induces Apoptosis and cell cycle arrest at G2/M phase when combinanted with CPT-11 (HY-16562). ATM Inhibitor-7 combines with CPT-11 shows antitumor activity[1].

Cat. No. Product Name Purity Description
HY-149291 ATM Inhibitor-7 ATM Inhibitor-7 is a potent and selective ataxia-telangiectasia mutated (ATM) inhibitor with an IC50 value of 1.0 nM. ATM Inhibitor-7 induces Apoptosis and cell cycle arrest at G2/M phase when combinanted with CPT-11 (HY-16562). ATM Inhibitor-7 combines with CPT-11 shows antitumor activity.

References

[1]. Shiyu Zhang, et al. Discovery of [1,2,3]Triazolo[4,5-c]quinoline Derivatives as a New Class of Ataxia-Telangiectasia Mutated Kinase Inhibitors. ACS Med. Chem. Lett. 2023.

Keywords:

ATM Inhibitor-7