2. Anti-infection
  3. Virus Protease
  4. 2306328-43-6

2306328-43-6

GS-9770 Chemical Structure

2306328-43-6

Chemical Structure

  • GS-9770
  • CAS No: 2306328-43-6
    Formula: C35H34ClF7N10O3
    Molecular Weight: 811.15
  • InChIKey: PZNXPIKYOCIJGV-QCBOHVIISA-N
  • SMILES: CC(C(F)(F)F)(C[C@@]1(C2=CC=C(C=C2)C3=NN(N=C3)C4CC4)C(N(C(N1)=N)[C@@H](C5=CC=C(C(C6=NC=NN6C(F)F)=C5)Cl)COC(NC7(C(F)F)CC7)=O)=O)C

Biological Activity: GS-9770 is an orally active inhibitor for HIV protease with Ki of 0.16 nM. GS-9770 exhibits antiviral activity aginst HIV-1 strains and HIV-2 strains with EC50 of 1.9-26 nM, and 26 nM. GS-9770 is metabolic stable in human liver microsomes. GS-9770 exhibits good pharmacokinetic characters in Sprague Dawley rats[1].

Cat. No. Product Name Purity Description
HY-162525 GS-9770 GS-9770 is an orally active inhibitor for HIV protease with Ki of 0.16 nM. GS-9770 exhibits antiviral activity aginst HIV-1 strains and HIV-2 strains with EC50 of 1.9-26 nM, and 26 nM. GS-9770 is metabolic stable in human liver microsomes. GS-9770 exhibits good pharmacokinetic characters in Sprague Dawley rats.

References

[1]. Mulato A, et al., Preclinical characterization of a non-peptidomimetic HIV protease inhibitor with improved metabolic stability. Antimicrob Agents Chemother. 2024 Apr 3;68(4):e0137323. [Content Brief]

Keywords:

GS-9770