2. PI3K/Akt/mTOR
  3. PI3K
  4. 3051828-81-7

3051828-81-7

PI3Kδ-IN-23 Chemical Structure

3051828-81-7

Chemical Structure

  • PI3Kδ-IN-23
  • CAS No: 3051828-81-7
    Formula: C30H30N6O5
    Molecular Weight: 554.60
  • InChIKey: IKONUSTXITZHRM-NRFANRHFSA-N
  • SMILES: O=C(OC1=CC=CC=C1)C2=CC(C3=NC(C(N[C@@H]4CN(CC4)C(C5CCOCC5)=O)=NC=N6)=C6C=C3)=CN=C2OC

Biological Activity: PI3Kδ-IN-23 (compound A11) is a potent inhibitor of PI3Kδ, with the IC50 of 0.27 nM. PI3Kδ-IN-23 bounds to PI3Kδ by covalent-bonding interactions with Lys779. PI3Kδ-IN-23 plays an important role in cancer research[1].

Cat. No. Product Name Purity Description
HY-169983 PI3Kδ-IN-23 PI3Kδ-IN-23 (compound A11) is a potent inhibitor of PI3Kδ, with the IC50 of 0.27 nM. PI3Kδ-IN-23 bounds to PI3Kδ by covalent-bonding interactions with Lys779. PI3Kδ-IN-23 plays an important role in cancer research.

References

[1]. Bo Yuan, et al. Lysine-Targeted Covalent Inhibitors of PI3Kδ Synthesis and Screening by In Situ Interaction Upgradation. J Med Chem. 2024 Nov 28;67(22):20076-20099. [Content Brief]

Keywords:

PI3Kδ-IN-23