2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. 3057447-11-4

3057447-11-4

(S,R,S)-AHPC-CO-PEG-C2-iodine Chemical Structure

3057447-11-4

Chemical Structure

  • (S,R,S)-AHPC-CO-PEG-C2-iodine
  • CAS No: 3057447-11-4
    Formula: C27H37IN4O5S
    Molecular Weight: 656.58
  • SMILES: ICCOCCC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(N=CS3)C)C=C2)=O)=O)=O

Biological Activity: (S,R,S)-AHPC-CO-PEG-C2-iodine is an E3 ligase (VHL) ligand-linker conjugate, and can be used for synthesis of PROTACs, such as PROTAC FAK degrader 1 (HY-119932)[1]

References

[1]. Cromm PM, et al. Addressing Kinase-Independent Functions of Fak via PROTAC-Mediated Degradation. J Am Chem Soc. 2018 Dec 12;140(49):17019-17026. [Content Brief]

Keywords:

(S,R,S)-AHPC-CO-PEG-C2-iodine