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  3. Biochemical Assay Reagents
  4. 21416-88-6

21416-88-6

ICRF-193 Chemical Structure

21416-88-6

Chemical Structure

  • ICRF-193
  • CAS No: 21416-88-6
    Formula: C12H18N4O4
    Molecular Weight: 282.30
  • IUPAC Name: 4,4'-((2R,3S)-butane-2,3-diyl)bis(piperazine-2,6-dione)
  • InChIKey: OBYGAPWKTPDTAS-OCAPTIKFSA-N
  • SMILES: C[C@@H]([C@@H](C)N(CC(N1)=O)CC1=O)N(CC(N2)=O)CC2=O

Biological Activity: ICRF-193 is an TopoII inhibitor. (S,S)- and (R,R)-isomers ICRF-193 make up an racemic mixture, ICRF-196 (HY-118590A). ICRF-196 can be used for the research of cancer[1].

Cat. No. Product Name Purity Description
HY-118590 ICRF-193 ≥98.0% ICRF-193 is an TopoII inhibitor. (S,S)- and (R,R)-isomers ICRF-193 make up an racemic mixture, ICRF-196 (HY-118590A). ICRF-196 can be used for the research of cancer.

References

[1]. Snapka RM,et al. Inhibition of topoisomerase II by ICRF-193, the meso isomer of 2,3-bis(2,6-dioxopiperazin-4-yl)butane. Critical dependence on 2,3-butanediyl linker absolute configuration. Biochem Pharmacol. 1996;52(4):543-549. [Content Brief]

Keywords:

ICRF-193