2. Epigenetics Immunology/Inflammation Apoptosis
  3. Histone Demethylase PD-1/PD-L1 Apoptosis
  4. 151390-97-5

151390-97-5

2’-O-Propargyladenosine Chemical Structure

151390-97-5

Chemical Structure

  • 2’-O-Propargyladenosine
  • CAS No: 151390-97-5
    Formula: C13H15N5O4
    Molecular Weight: 305.29
  • IUPAC Name: (2R,3S,4S,5R)-5-(6-amino-9H-purin-9-yl)-2-(hydroxymethyl)-4-(prop-2-yn-1-yloxy)tetrahydrofuran-3-ol
  • InChIKey: ROHGEAZREAFNTO-SQFXPHBZSA-N
  • SMILES: OC[C@@H]1[C@@H](O)[C@@H](OCC#C)[C@H](N(C=N2)C3=C2C(N)=NC=N3)O1

Biological Activity: 2’-O-Propargyladenosine is an adenosine analogue. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. The popular products in this series are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277)[1]. 2’-O-Propargyladenosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No. Product Name Purity Description
HY-152744 2’-O-Propargyladenosine 2’-O-Propargyladenosine is an adenosine analogue. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. The popular products in this series are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277). 2’-O-Propargyladenosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

References

[1]. Man S, et al. Potential and promising anticancer drugs from adenosine and its analogs. Drug Discov Today. 2021 Jun;26(6):1490-1500. [Content Brief]

Keywords:

2’-O-Propargyladenosine