1. PI3K/Akt/mTOR Cell Cycle/DNA Damage Autophagy Apoptosis
  2. PI3K mTOR DNA-PK Autophagy Apoptosis
  3. 1401924-49-9

1401924-49-9

NVP018 Chemical Structure

1401924-49-9

Chemical Structure

  • NVP018
  • Synonym(s): BC556
  • CAS No: 1401924-49-9
    Formula: C45H62FN5O11
    Molecular Weight: 868.00
  • IUPAC Name: (3S,6S,9R,10R,11S,12S,13E,15E,18S,21S)-18-((2E,4E)-6-(1,2-oxazinan-2-yl)-6-oxohexa-2,4-dien-2-yl)-3-(3-fluoro-5-hydroxybenzyl)-10,12-dihydroxy-6-isopropyl-11-methyl-9-(3-oxobutyl)-19-oxa-1,4,7,25-tetraazabicyclo[19.3.1]pentacosa-13,15-diene-2,5,8,20-tetra
  • InChIKey: CFLBTKFHBBDVKC-RADSUMAKSA-N
  • SMILES: O=C(N1N[C@](CCC1)([H])C(O[C@@H](C/C=C/C=C/[C@@H]([C@@H]([C@H]([C@H](C(N[C@H](C(N2)=O)C(C)C)=O)CCC(C)=O)O)C)O)/C(C)=C/C=C/C(N3CCCCO3)=O)=O)[C@@H]2CC4=CC(F)=CC(O)=C4

Biological Activity: NVP018 (BC556) is an orally active inhibitor for cyclophilin A with IC50 of 0.3 and 0.1 nM for cyclophilin A and NS5A- cyclophilin A complex. NVP018 inhibits Bilirubin (HY-N0323) transporter OATP1B1 and OATP1B3 with IC50 of 4.31 and 1.75 μM. NVP018 inhibits the replication of HBV (in HepG2), HCV (in Huh-7) and HIV-1 (in HeLa), with IC50 in nanomolar levels. NVP018 exhibits anti-fibrotic effect by inhibiting the mRNA expression of COL1A1 and LOX[1][2].

Cat. No. Product Name Purity Description
HY-125640 NVP018 NVP018 (BC556) is an orally active inhibitor for cyclophilin A with IC50 of 0.3 and 0.1 nM for cyclophilin A and NS5A- cyclophilin A complex. NVP018 inhibits Bilirubin (HY-N0323) transporter OATP1B1 and OATP1B3 with IC50 of 4.31 and 1.75 μM. NVP018 inhibits the replication of HBV (in HepG2), HCV (in Huh-7) and HIV-1 (in HeLa), with IC50 in nanomolar levels. NVP018 exhibits anti-fibrotic effect by inhibiting the mRNA expression of COL1A1 and LOX.

References

Keywords:

NVP018