2. Protein Tyrosine Kinase/RTK Anti-infection Metabolic Enzyme/Protease
  3. VEGFR HCV Endogenous Metabolite
  4. 38101-59-6

38101-59-6

Oglufanide Chemical Structure

38101-59-6

Chemical Structure

  • Oglufanide
  • Synonym(s): H-Glu-Trp-OH; L-Glutamyl-L-tryptophan
  • CAS No: 38101-59-6
    Formula: C16H19N3O5
    Molecular Weight: 333.34
  • IUPAC Name: (S)-4-amino-5-(((S)-1-carboxy-2-(1H-indol-3-yl)ethyl)amino)-5-oxopentanoic acid
  • InChIKey: LLEUXCDZPQOJMY-AAEUAGOBSA-N
  • SMILES: O=C(O)[C@H](CC1=CNC2=CC=CC=C12)NC([C@H](CCC(O)=O)N)=O

Biological Activity: Oglufanide (H-Glu-Trp-OH) is a dipeptide immunomodulator isolated from calf thymus. Oglufanide inhibits vascular endothelial growth factor (VEGF). Oglufanide can stimulate the immune response to hepatitic C virus (HCV) and intracellular bacterial infections. Oglufanide shows antitumor and anti-angiogenesis activities[1][2][3].

Cat. No. Product Name Purity Description
HY-13718 Oglufanide 98.97% Oglufanide (H-Glu-Trp-OH) is a dipeptide immunomodulator isolated from calf thymus. Oglufanide inhibits vascular endothelial growth factor (VEGF). Oglufanide can stimulate the immune response to hepatitic C virus (HCV) and intracellular bacterial infections. Oglufanide shows antitumor and anti-angiogenesis activities.

References

[1]. Bayes M, et al. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2005 Jul-Aug;27(6):411-61. [Content Brief]
[2]. Nagendra Kumar Kaushik, et al. Biomedical importance of indoles. Molecules. 2013 Jun 6;18(6):6620-62. [Content Brief]
[3]. Noy A, et al. Angiogenesis inhibitor IM862 is ineffective against AIDS-Kaposi's sarcoma in a phase III trial, but demonstrates sustained, potent effect of highly active antiretroviral therapy: from the AIDS Malignancy Consortium and IM862 Study Team. J Clin Oncol. 2005 Feb 10;23(5):990-8. [Content Brief]

Keywords:

Oglufanide