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  5. Calophyllum inophyllum L.
  6. 57343-54-1

57343-54-1

DQn-1 Chemical Structure

57343-54-1

Chemical Structure

  • DQn-1
  • CAS No: 57343-54-1
    Formula: C16H14ClN5O2
    Molecular Weight: 343.77
  • IUPAC Name: 4-(((2,4-diamino-5-chloroquinazolin-6-yl)methyl)amino)benzoic acid
  • InChIKey: OARHSEZBVKKLFI-UHFFFAOYSA-N
  • SMILES: O=C(C1=CC=C(NCC2=CC=C3N=C(N)N=C(C3=C2Cl)N)C=C1)O

Biological Activity: DQn-1 is a potent antifolate with activity against Mycobacterium tuberculosis (Mtb) (MIC90=0.03 µM). DQn-1 directly inhibits DHFR enzyme activity, with IC50s of 8.7 and 7.6 nM for Mtb and human DHFR enzyme, respectively[1].

Cat. No. Product Name Purity Description
HY-154807 DQn-1 DQn-1 is a potent antifolate with activity against Mycobacterium tuberculosis (Mtb) (MIC90=0.03 µM). DQn-1 directly inhibits DHFR enzyme activity, with IC50s of 8.7 and 7.6 nM for Mtb and human DHFR enzyme, respectively.

References

[1]. Kumar A, et, al. A Focused Screen Identifies Antifolates with Activity on Mycobacterium tuberculosis. ACS Infect Dis. 2015 Dec 11;1(12):604-14. [Content Brief]

Keywords:

DQn-1